What is ovarian cancer ?

Ovarian cancers are malignant tumors that develop from ovarian cells or from cells of the fallopian tubes.

💡 DID YOU KNOW ?

The ovaries are two organs located in the lower abdomen ( pelvic cavity or small pelvis ) on either side of the uterus. They are small, oval-shaped, flat organs, about 4 cm long and 1.5 cm thick.

The main functions of the ovaries are :

  • The production of eggs (ova)
  • The production of hormones involved in regulating reproduction and the development of sexual characteristics

The ovaries are made up of three different types of cells :

  • Epithelial cells , which form the outer layer of the ovaries called the epithelium
  • Ovarian follicles , located beneath the epithelial cells, from which the eggs are produced. The ovaries contain about 400,000 follicles present at birth. After puberty, one follicle matures during each menstrual cycle. On average, on the fourteenth day of the cycle, this mature follicle releases a fertilizable egg that migrates toward the uterus. After ovulation, some of the cells from the follicle, once the egg is released, transform into the corpus luteum during the second half of the ovarian cycle.
  • Stromal cells (a connective tissue filling the interior of the ovaries) and sex cords , which link the body of the ovary to the epithelial surface.

Each of these cell types can give rise to cancer. Epithelial cancer (serous or mucinous carcinoma) is the most common type of ovarian cancer. The fallopian tubes connect the ovaries to the uterus. Their role is to receive the egg from the ovary and allow it to migrate toward the uterus. The cells of the fallopian tubes may be responsible for some ovarian cancers.

As cancer cells multiply, the tumor grows and may break through the capsule surrounding the ovary. Cancer cells can then escape into the pelvis and invade neighboring organs, including the fallopian tubes, uterus, bladder, rectum, and the other ovary. This is referred to as pelvic or locoregional extension.

The cancer cells can then spread beyond the pelvis to the peritoneum or the lymph nodes in the abdomen.

Ovarian cancer is the 9th leading cause of cancer in women. The most common ovarian tumors (90%) are epithelial tumors or adenocarcinomas (ESMO 2013).

In France, the number of new cases diagnosed in 2020 was estimated to be 5 320.

The incidence of these cancers (number of new cases per year) has been decreasing since 1990, and this trend has accelerated since 2005. Ovarian cancer typically appears after menopause, but rarer forms may develop earlier, sometimes as early as adolescence.

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Article updated on Jan 9, 2025

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